ACETYLSALICYLIC ACID RESISTANCE IN PATIENTS WITH ACUTE CORONARY SYNDROME AND ITS RELATIONSHIP BETWEEN MEAN PLATELET VOLUME

Objective: Insufficient biochemical response to Acetylsalicylic Acid (ASA) is defined as 'ASA resistance'. Its prevalence is unknown. The frequency of death and cardiovascular events rises as the mean platelet volume (MPV) increases in patients with acute coronary syndrome (ACS). Patients with high MPV are more resistant to antiplatelet agents. Our study aimed to evaluate the temporal variability of ASA resistance and platelet reactivity in ACS patients and to demonstrate its relationship with MPV. Material and Methods: Our study is single-center prospective, cross-sectional study. Patients over 18 years of age who were hospitalized due to ACS and underwent percutaneous coronary intervention were included. ASA resistance and MPV measurements were taken at admission and first month. The prevalence and alteration of ASA resistance and its relationship with MPV were analyzed. Results: 115 patients were included in the study. 7 patients (6.08%) were ASA-resistant at first admission and increased to 22 (19.13%) at the 1st month follow-up (p=0.003). A significant numerical increase in ASA resistance was observed in the first month of controls (p<0.01). The prevalence of ASA resistance was calculated as 22.6%. MPV was found to be high in 16 patients (13.9%) at the time of admission, while it was found to be high in 15 patients (13.04%) at the 1-month follow-up (p=0.98). MPV values were found to be similar in patients with and without ASA resistance. Conclusion: ASA resistance is more common than thought. Therefore, evaluating platelet functions in predicting the clinical outcomes of patients is important in determining the effectiveness of the antiplatelet agent used.