EFFICACY AND SAFETY OF POSTOPERATIVE INTRAVESICAL ADMINISTRATION OF TRANEXAMIC ACID AFTER TRANSURETHRAL RESECTION OF THE PROSTATE*

Objective: To evaluate the safety and efficacy of postoperative intravesical administration of tranexamic acid after transurethral resection of the prostate. Material and Method: The data of 112 patients who underwent surgery for lower urinary tract symptoms associated with benign prostatic obstruction (BPO) were retrospectively analysed. We formed two groups: Group 1 consisted of 57 patients who received tranexamic acid by irrigation fluid after the operation; group 2 consisted of 55 patients who did not receive tranexamic acid. Demographic data of patients and prostate characters, as well as operative and postoperative data were analysed. Postoperative bleeding in all patients was evaluated using the haemoglobin levels at the preoperative, and at 0- and 24-h postoperative were evaluated and noted. Result: The mean ages of the patients were 66.9±7.2 (55-81) years in the intervention group, and those in the control group were 68.6±7.6 (55-80) years. There were no significant differences between the groups for demographic data, prostate volume and International Prostate Symptom Score (IPSS). The reduction in Hb at 24 hours postoperatively was greater in the control group compared to the tranexamic acid (TXA) group. Statistically significant differences were found between the two groups in terms of postoperative haemoglobin decrease, bladder irrigation time and total amount of irrigation fluid. There were no statistically significant differences between each group regarding the operation, weight of resected adenoma, hospitalization time and catheter removal time. Conclusion: A postoperative follow-up process with less bleeding and complications is possible with tranexamic acid added to the intravesical irrigation fluid used after transurethral prostate resection (TURP) surgery.